論文

Publications

 


Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.


All Publications

169 entries « 1 of 9 »
1. Kasuba, Krishna Chaitanya; Buccino, Alessio Paolo; Bartram, Julian; Gaub, Benjamin M; Fauser, Felix J; Ronchi, Silvia; Kumar, Sreedhar Saseendran; Geissler, Sydney; Nava, Michele M; Hierlemann, Andreas; Müller, Daniel J: Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks. In: Nature Nanotechnology, 2024. (Type: Journal Article | Abstract | Links | BibTeX)
2. Hruska-Plochan, Marian; Wiersma, Vera I; Betz, Katharina M; Mallona, Izaskun; Ronchi, Silvia; Maniecka, Zuzanna; Hock, Eva-Maria; Tantardini, Elena; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Pérez-Berlanga, Manuela; Gatta, Beatrice; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Sharma, Puneet; Vos, Laura De; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini: A model of human neural networks reveals NPTX2 pathology in ALS and FTLD. In: Nature, 2024. (Type: Journal Article | Abstract | Links | BibTeX)
3. Hornauer, Philipp; Prack, Gustavo; Anastasi, Nadia; Ronchi, Silvia; Kim, Taehoon; Donner, Christian; Fiscella, Michele; Borgwardt, Karsten; Taylor, Verdon; Jagasia, Ravi; Roqueiro, Damian; Hierlemann, Andreas; Schröter, Manuel: DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks. In: Stem Cell Reports, 2024. (Type: Journal Article | Abstract | Links | BibTeX)
4.van der Molen, Tjitse; Spaeth, Alex; Chini, Mattia; Bartram, Julian; Dendukuri, Aditya; Zhang, Zongren; Bhaskaran-Nair, Kiran; Blauvelt, Lon J; Petzold, Linda R; Hansma, Paul K; Teodorescu, Mircea; Hierlemann, Andreas; Hengen, Keith B; Hanganu-Opatz, Ileana L; Kosik, Kenneth S; Sharf, Tal: Protosequences in human cortical organoids model intrinsic states in the developing cortex. In: bioRxiv, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
5. Ryu, Seungmi; Weber, Claire; Chu, Pei-Hsuan; Ernest, Ben; Jovanovic, Vukasin M; Deng, Tao; Slamecka, Jaroslav; Hong, Hyenjong; Jethmalani, Yogita; Baskir, Hannah M; Inman, Jason; Braisted, John; Hirst, Marissa B; Simeonov, Anton; Voss, Ty C; Tristan, Carlos A; Singeç, Ilyas: Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness. In: Biofabrication, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
6. Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; Guo, Feng: Brain organoid reservoir computing for artificial intelligence. In: Nature Electronics, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
7. Elliott, Matthew A T; Schweiger, Hunter E; Robbins, Ash; Vera-Choqqueccota, Samira; Ehrlich, Drew; Hernandez, Sebastian; Voitiuk, Kateryna; Geng, Jinghui; Sevetson, Jess L; Core, Cordero; Rosen, Yohei M; Teodorescu, Mircea; Wagner, Nico O; Haussler, David; Mostajo-Radji, Mohammed A: Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education. In: eNeuro, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
8. Tamatani, Chie; Shimba, Kenta; andYasuhiko Jimbo, Kiyoshi Kotani: Activity- and Spatial-dependent Variations in Axonal Conduction Recorded from Microtunnel Electrodes. IEEE Xplore, 2023. (Type: Conference | Abstract | Links | BibTeX)
9. Kobayashi, Toki; Shimba, Kenta; Kotani, Kiyoshi; Jimbo, Yasuhiko: Measuring and Inducing the Plasticity of Single-Neuron Scale at Multiple Points. ISSS Xplore, 2023. (Type: Conference | Abstract | Links | BibTeX)
10. Sawada, Tomoyo; Barbosa, André R; Araujo, Bruno; McCord, Alejandra E; D’Ignazio, Laura; Benjamin, Kynon J M; Sheehan, Bonna; Zabolocki, Michael; Feltrin, Arthur; Arora, Ria; Brandtjen, Anna C; Kleinman, Joel E; Hyde, Thomas M; Bardy, Cedric; Weinberger, Daniel R; Paquola, Apuã C M; Erwin, Jennifer A: Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia. In: American Journal of Psychiatry, 2023, ISSN: 0002-953X. (Type: Journal Article | Abstract | Links | BibTeX)
11. Duru, Jens; Rüfenacht, Arielle; Löhle, Josephine; Pozzi, Marcello; Forró, Csaba; Ledermann, Linus; Bernardi, Aeneas; Matter, Michael; Renia, André; Simona, Benjamin; Tringides, Christina M; Bernhard, Stéphane; Ihle, Stephan J; Hengsteler, Julian; Maurer, Benedikt; Zhanga, Xinyu; Nakatsuka, Nako: Driving electrochemical reactions at the microscale using CMOS microelectrode arrays. In: Lab on a Chip, 2023, ISSN: 1473-0189. (Type: Journal Article | Abstract | Links | BibTeX)
12. Kelley, Matt R; Chipman, Laura B; Asano, Shoh; Knott, Matthew; Howard, Samantha T; Berg, Allison P: Potentiating NaV1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony. In: bioRxiv, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
13. Metto, Abigael C; Telgkamp, Petra; McLane-Svoboda, Autumn K; Gilad, Assaf A; Pelled, Galit: Closed-loop neurostimulation via expression of magnetogenetics-sensitive protein in inhibitory neurons leads to reduction of seizure activity in a rat model of epilepsy. In: Brain Research, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
14. Levi, Timothee; Beaubois, Romain; Cheslet, Jérémy; Duenki, Tomoya; Khoyratee, Farad; Branchereau, Pascal; Ikeuchi, Yoshiho: BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network. In: Research Square, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
15. Silverman, Jill L; Fenton, Timothy; Haouchine, Olivia; Hallam, Elizabeth; Smith, Emily; Jackson, Kiya; Rahbarian, Darlene; Canales, Cesar; Adhikari, Anna; Nord, Alex; Ben-Shalom, Roy: Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1mutations. In: Research Square, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
16. Habibollahi, Forough; Kagan, Brett J; Burkitt, Anthony N; French, Chris: Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks. In: Nature Communications, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
17. Radivojevic, Milos; Punga, Anna Rostedt: Functional imaging of conduction dynamics in cortical and spinal axons. In: eLife, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
18. Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János: Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays. In: Biosensors and Bioelectronics, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
19. Yamamoto, Hideaki; Hirano-Iwata, Ayumi; Sato, Shigeo: Microfluidic technologies for reconstituting neuronal network functions in vitro. In: JSAP Review, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
20. Zhao, Eric T; Hull, Jacob M; Hemed, Nofar Mintz; Ulusan, Hasan; Bartram, Julian; Zhang, Anqi; Wang, Pingyu; Pham, Albert; Silvia Ronchi, John Huguenard R; Hierlemann, Andreas; Melosh, Nicholas A: A CMOS-based highly scalable flexible neural electrode interface. In: Science Advances, 2023. (Type: Journal Article | Abstract | Links | BibTeX)
169 entries « 1 of 9 »

169 entries « 1 of 4 »

2024

Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks

Kasuba, Krishna Chaitanya; Buccino, Alessio Paolo; Bartram, Julian; Gaub, Benjamin M; Fauser, Felix J; Ronchi, Silvia; Kumar, Sreedhar Saseendran; Geissler, Sydney; Nava, Michele M; Hierlemann, Andreas; Müller, Daniel J

Mechanical stimulation and electrophysiological monitoring at subcellular resolution reveals differential mechanosensation of neurons within networks Journal Article

Nature Nanotechnology, 2024.

Abstract | Links | BibTeX | タグ: Action Potential, Brain Slice, HD-MEA, MaxOne, Primary Neuronal Cell Culture, Spike Sorting

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD

Hruska-Plochan, Marian; Wiersma, Vera I; Betz, Katharina M; Mallona, Izaskun; Ronchi, Silvia; Maniecka, Zuzanna; Hock, Eva-Maria; Tantardini, Elena; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Pérez-Berlanga, Manuela; Gatta, Beatrice; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Sharma, Puneet; Vos, Laura De; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD Journal Article

Nature, 2024.

Abstract | Links | BibTeX | タグ: Activity Scan Assay, HD-MEA, IPSC, MaxOne, MEA Technology, Network Assay, Primary Neuronal Cell Culture, Spike Sorting

DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks

Hornauer, Philipp; Prack, Gustavo; Anastasi, Nadia; Ronchi, Silvia; Kim, Taehoon; Donner, Christian; Fiscella, Michele; Borgwardt, Karsten; Taylor, Verdon; Jagasia, Ravi; Roqueiro, Damian; Hierlemann, Andreas; Schröter, Manuel

DeePhys: A machine learning–assisted platform for electrophysiological phenotyping of human neuronal networks Journal Article

Stem Cell Reports, 2024.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, IPSC, MaxOne, MEA Technology, Spike Sorting

2023

Protosequences in human cortical organoids model intrinsic states in the developing cortex

van der Molen, Tjitse; Spaeth, Alex; Chini, Mattia; Bartram, Julian; Dendukuri, Aditya; Zhang, Zongren; Bhaskaran-Nair, Kiran; Blauvelt, Lon J; Petzold, Linda R; Hansma, Paul K; Teodorescu, Mircea; Hierlemann, Andreas; Hengen, Keith B; Hanganu-Opatz, Ileana L; Kosik, Kenneth S; Sharf, Tal

Protosequences in human cortical organoids model intrinsic states in the developing cortex Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | タグ: MaxOne, Organoids

Brain organoid reservoir computing for artificial intelligence

Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; Guo, Feng

Brain organoid reservoir computing for artificial intelligence Journal Article

Nature Electronics, 2023.

Abstract | Links | BibTeX | タグ: 3D Culture, HD-MEA, Machine Learning, MaxOne, MEA Technology, Organoids, Stimulation

Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness

Ryu, Seungmi; Weber, Claire; Chu, Pei-Hsuan; Ernest, Ben; Jovanovic, Vukasin M; Deng, Tao; Slamecka, Jaroslav; Hong, Hyenjong; Jethmalani, Yogita; Baskir, Hannah M; Inman, Jason; Braisted, John; Hirst, Marissa B; Simeonov, Anton; Voss, Ty C; Tristan, Carlos A; Singeç, Ilyas

Stress-free cell aggregation by using the CEPT cocktail enhances embryoid body and organoid fitness Journal Article

Biofabrication, 2023.

Abstract | Links | BibTeX | タグ: 3D Culture, Activity Scan Assay, HD-MEA, MEA Technology, Organoids

Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education

Elliott, Matthew A T; Schweiger, Hunter E; Robbins, Ash; Vera-Choqqueccota, Samira; Ehrlich, Drew; Hernandez, Sebastian; Voitiuk, Kateryna; Geng, Jinghui; Sevetson, Jess L; Core, Cordero; Rosen, Yohei M; Teodorescu, Mircea; Wagner, Nico O; Haussler, David; Mostajo-Radji, Mohammed A

Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education Journal Article

eNeuro, 2023.

Abstract | Links | BibTeX | タグ: 3D Culture, Activity Scan Assay, HD-MEA, IPSC, MaxOne, MEA Technology, Organoids, Spike Sorting, Stimulation

Measuring and Inducing the Plasticity of Single-Neuron Scale at Multiple Points

Kobayashi, Toki; Shimba, Kenta; Kotani, Kiyoshi; Jimbo, Yasuhiko

Measuring and Inducing the Plasticity of Single-Neuron Scale at Multiple Points Conference

ISSS Xplore, 2023.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Primary Neuronal Cell Culture, Stimulation

Activity- and Spatial-dependent Variations in Axonal Conduction Recorded from Microtunnel Electrodes

Tamatani, Chie; Shimba, Kenta; andYasuhiko Jimbo, Kiyoshi Kotani

Activity- and Spatial-dependent Variations in Axonal Conduction Recorded from Microtunnel Electrodes Conference

IEEE Xplore, 2023.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne

Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia

Sawada, Tomoyo; Barbosa, André R; Araujo, Bruno; McCord, Alejandra E; D’Ignazio, Laura; Benjamin, Kynon J M; Sheehan, Bonna; Zabolocki, Michael; Feltrin, Arthur; Arora, Ria; Brandtjen, Anna C; Kleinman, Joel E; Hyde, Thomas M; Bardy, Cedric; Weinberger, Daniel R; Paquola, Apuã C M; Erwin, Jennifer A

Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donor’s Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia Journal Article

American Journal of Psychiatry, 2023, ISSN: 0002-953X.

Abstract | Links | BibTeX | タグ: 3D Culture, Activity Scan Assay, HD-MEA, MaxTwo, Network Assay, Organoids

Driving electrochemical reactions at the microscale using CMOS microelectrode arrays

Duru, Jens; Rüfenacht, Arielle; Löhle, Josephine; Pozzi, Marcello; Forró, Csaba; Ledermann, Linus; Bernardi, Aeneas; Matter, Michael; Renia, André; Simona, Benjamin; Tringides, Christina M; Bernhard, Stéphane; Ihle, Stephan J; Hengsteler, Julian; Maurer, Benedikt; Zhanga, Xinyu; Nakatsuka, Nako

Driving electrochemical reactions at the microscale using CMOS microelectrode arrays Journal Article

Lab on a Chip, 2023, ISSN: 1473-0189.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Primary Neuronal Cell Culture, Stimulation

Potentiating NaV1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony

Kelley, Matt R; Chipman, Laura B; Asano, Shoh; Knott, Matthew; Howard, Samantha T; Berg, Allison P

Potentiating NaV1.1 in Dravet syndrome patient iPSC-derived GABAergic neurons increases neuronal firing frequency and decreases network synchrony Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | タグ: Activity Scan Assay, Axon Tracking Assay, HD-MEA, IPSC, MaxTwo, MEA Technology, Network Assay, Spike Sorting

Closed-loop neurostimulation via expression of magnetogenetics-sensitive protein in inhibitory neurons leads to reduction of seizure activity in a rat model of epilepsy

Metto, Abigael C; Telgkamp, Petra; McLane-Svoboda, Autumn K; Gilad, Assaf A; Pelled, Galit

Closed-loop neurostimulation via expression of magnetogenetics-sensitive protein in inhibitory neurons leads to reduction of seizure activity in a rat model of epilepsy Journal Article

Brain Research, 2023.

Abstract | Links | BibTeX | タグ: 3D Culture, closed loop stimulation, HD-MEA, MaxOne, Slices

BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network

Levi, Timothee; Beaubois, Romain; Cheslet, Jérémy; Duenki, Tomoya; Khoyratee, Farad; Branchereau, Pascal; Ikeuchi, Yoshiho

BiœmuS: A new tool for neurological disorders studies through real-time emulation and hybridization using biomimetic Spiking Neural Network Journal Article

Research Square, 2023.

Abstract | Links | BibTeX | タグ: closed loop stimulation, MaxOne, MEA Technology, Organoids

Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1mutations

Silverman, Jill L; Fenton, Timothy; Haouchine, Olivia; Hallam, Elizabeth; Smith, Emily; Jackson, Kiya; Rahbarian, Darlene; Canales, Cesar; Adhikari, Anna; Nord, Alex; Ben-Shalom, Roy

Hyperexcitability and translational phenotypes in a preclinical model of SYNGAP1mutations Journal Article

Research Square, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Activity Scan Assay, HD-MEA, MaxOne, Network Assay, Primary Neuronal Cell Culture

Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks

Habibollahi, Forough; Kagan, Brett J; Burkitt, Anthony N; French, Chris

Critical dynamics arise during structured information presentation within embodied in vitro neuronal networks Journal Article

Nature Communications, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, IPSC, MaxOne, MEA Metrics, MEA Technology, Primary Neuronal Cell Culture

Functional imaging of conduction dynamics in cortical and spinal axons

Radivojevic, Milos; Punga, Anna Rostedt

Functional imaging of conduction dynamics in cortical and spinal axons Journal Article

eLife, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Axon Tracking Assay, MaxOne, MEA Technology, Primary Neuronal Cell Culture

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays

Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays Journal Article

Biosensors and Bioelectronics, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, MaxOne, Stimulation

Microfluidic technologies for reconstituting neuronal network functions in vitro

Yamamoto, Hideaki; Hirano-Iwata, Ayumi; Sato, Shigeo

Microfluidic technologies for reconstituting neuronal network functions in vitro Journal Article

JSAP Review, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, MaxOne, MEA Technology, Microfluidics

A CMOS-based highly scalable flexible neural electrode interface

Zhao, Eric T; Hull, Jacob M; Hemed, Nofar Mintz; Ulusan, Hasan; Bartram, Julian; Zhang, Anqi; Wang, Pingyu; Pham, Albert; Silvia Ronchi, John Huguenard R; Hierlemann, Andreas; Melosh, Nicholas A

A CMOS-based highly scalable flexible neural electrode interface Journal Article

Science Advances, 2023.

Abstract | Links | BibTeX | タグ: 3D Culture, HD-MEA, MaxOne, Other Tissues, Slices

Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules

Girardi, Gregory; Zumpano, Danielle; Goshi, Noah; Raybould, Helen; Seker, Erkin

Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules Journal Article

biosensors, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, MaxOne, MEA Technology, Primary Neuronal Cell Culture

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking Journal Article

eLife, 2023.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, MEA Metrics, MEA Technology, Modeling, Primary Neuronal Cell Culture, Spike Sorting

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays

Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays Journal Article

SSRN, 2023.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, MEA Technology, Primary Neuronal Cell Culture, Spike Sorting, Stimulation

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, He Jax; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Yang, Xianfa; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

Cell Regeneration, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Activity Scan Assay, Axon Tracking Assay, HD-MEA, IPSC, MaxOne, MEA Technology, Network Assay, Organoids

Functional imaging of conduction dynamics in cortical and spinal axons

Radivojevic, Milos; Punga, Anna Rostedt

Functional imaging of conduction dynamics in cortical and spinal axons Journal Article

BioRxiv, 2023.

Abstract | Links | BibTeX | タグ: MaxOne

Brain Organoid Computing for Artificial Intelligence

Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; and Guo, Feng

Brain Organoid Computing for Artificial Intelligence Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | タグ: HD-MEA, Machine Learning, MaxOne, MEA Technology, Modeling, Organoids, Stimulation

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons

Lin, Waka; Shiomoto, Shusaku; Yamada, Saki; Watanabe, Hikaru; Kawashima, Yudai; Eguchi, Yuichi; Muramatsu, Koichi; Sekino, Yuko

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons Journal Article

iScience, 2023.

Abstract | Links | BibTeX | タグ: Activity Scan Assay, MaxTwo, Network Assay

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Qian, Junming; Guan, Xiaonan; Xie, Bing; Xu, Chuanyun; Niu, Jacqueline; Tang, Xin; Li, Charles H; Colecraft, Henry M; Jaenisch, Rudolf; Liu, Shawn X

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons Journal Article

Science Translational Medicine, 2023.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, HD-MEA, IPSC, MaxTwo, MEA Technology

A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

Kim, Eunhee; Jeon, Sungwoong; Yang, Yoon-Sil; Jin, Chaewon; Kim, Jin-young; Oh, Yong- Seok; Rah, Jong-Cheol; and Choi, Hongsoo

A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice Journal Article

Advanced Materials, 2023.

Abstract | Links | BibTeX | タグ: MaxOne, microrobot, Organoids, Slices

Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks

Kim, Taehoon; Chen, Dexiong; Hornauer, Philipp; Emmenegger, Vishalini; Bartram, Julian; Ronchi, Silvia; Hierlemann, Andreas; Schröter, Manuel; Roqueiro, Damian

Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks Journal Article

Frontiers in Neuroinformatics, 2023.

Abstract | Links | BibTeX | タグ: MaxTwo, Primary Neuronal Cell Culture

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato, Yuya; Yamamoto, Hideaki; Kato, Hideyuki; Tanii, Takashi; Sato, Shigeo; Hirano-Iwata, Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

Frontiers in Neuroscience, 2023.

Abstract | Links | BibTeX | タグ: MaxOne, Neuronal Networks

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | タグ: CMOS, HD-MEA, Modeling, Primary Neuronal Cell Culture, Spike Sorting

2022

A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement

Han, Xiaobo; Matsuda, Naoki; Ishibashi, Yuto; Odawara, Aoi; Takahashi, Sayuri; Tooi, Norie; Kinoshita, Koshi; Suzuki, Ikuro

A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement Journal Article

Biomaterials Research, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, IPSC, MaxOne, Neuronal cell culture, Organoids, Primary Neuronal Cell Culture

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A

Lent, Jonas Van; Vendredy, Leen; Adriaenssens, Elias; Authier, Tatiana Da Silva; Asselbergh, Bob; Kaji, Marcus; Weckhuysen, Sarah; Bosch, Ludo Van Den; Baets, Jonathan; Timmerman, Vincent

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A Journal Article

Brain, 2022.

Abstract | Links | BibTeX | タグ: Activity Scan Assay, Axon Tracking Assay, MaxTwo, Network Assay, Organoids

Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation

Tran, Hoang-Dai; Shin, Min-Kyoung; Denman, Charlotte; Han, Run-Run; Kuhn, Bernd; Arbuthnott, Gordon; Jo, Junghyun

Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation Journal Article

Sneak Peek - Cell Press, 2022.

Abstract | Links | BibTeX | タグ: MaxOne, Organoids

Homophilic wiring principles underpin neuronal network topology in vitro

Akarca, Danyal; Dunn, Alexander W E; Hornauer, Philipp J; Ronchi, Silvia; Fiscella, Michele; Wang, Congwei; Terrigno, Marco; Jagasia, Ravi; Vértes, Petra E; Mierau, Susanna B; Paulsen, Ole; Eglen, Stephen J; Hierlemann, Andreas; Astle, Duncan E; Schröter, Manuel

Homophilic wiring principles underpin neuronal network topology in vitro Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | タグ: MaxOne, MaxTwo, MEA Technology

Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world

Habibollahi, Forough; Khajehnejad, Moein; Gaurav, Amitesh; Kagan, Brett Joseph

Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world Conference

2022.

Abstract | Links | BibTeX | タグ: Machine Learning, MaxOne

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; and Pak, ChangHui

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons Journal Article

iScience, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, CMOS, CRISPR, HD-MEA, MaxOne, Synapses

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Habibollahi, Forough; Khajehnejad, Moein; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

Neuron, 2022.

Abstract | Links | BibTeX | タグ: CMOS, HD-MEA, IPSC, MaxOne, Primary Neuronal Cell Culture

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

Habibey, Rouhollah; Striebel, Johannes; Schmieder, Felix; Czarske, Jürgen; Busskamp, Volker

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne, MEA Metrics, Modeling, Spike Sorting

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Kumar, Sreedhar S; Gänswein, Tobias; Buccino, Alessio P; Xue, Xiaohan; Bartram, Julian; Emmenegger, Vishalini; Hierlemann, Andreas

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study Journal Article

Frontiers in Neuroinformatics, 2022.

Abstract | Links | BibTeX | タグ: CMOS, HD-MEA, MEA Technology

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

Lee, Jihyun; Gänswein, Tobias; Ulusan, Hasan; Emmenegger, Vishalini; Saguner, Ardan M; Duru, Firat; and Hierlemann, Andreas

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells Journal Article

ACS Sensors, 2022.

Abstract | Links | BibTeX | タグ: Cardiomyocytes, CMOS, HD-MEA, MaxOne, MEA Technology

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus

Al-Absi, Abdel-Rahman; Thambiappaa, Sakeerthi Kethees; Khanc, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Landau, Anne M; Nyengaard, Jens R

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus Journal Article

Molecular and Cellular Neuroscience, 2022.

Abstract | Links | BibTeX | タグ: Brain Slice, CMOS, HD-MEA, MaxOne

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Buccino Alessio Paolo; Damart, Tanguy; Bartram Julian; Mandge Darshan; Xue Xiaohan; Zbili Mickael; Gänswein Tobias; Jaquier Aurélien; Emmenegger Vishalini; Markram Henry; Hierlemann Andreas; Van Geit Werner.

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Activity Scan Assay, Axon Tracking Assay, HD-MEA, MaxOne, Other Tissues, Publication, Stimulation Assay

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan; Buccino, Alessio Paolo; Kumar, Sreedhar Saseendran; Hierlemann, Andreas; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

Journal of Neural Engineering, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, Activity Assay, HD-MEA, MaxOne, Network Assay, Primary Neuronal Cell Culture, Publication

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Sharf Tal; Molen, Tjitse; Glasauer Stella; Guzman Elmer; Buccino Alessio; Luna Gabriel; Cheng Zhuowei; Audouard Morgane; Ranasinghe Kamalini; Kudo Kiwamu; Nagarajan Srikantan; Tovar Kenneth; Petzold Linda; Hierlemann Andreas; Hansma Paul; ; Kosik, Kenneth;

Functional neuronal circuitry and oscillatory dynamics in human brain organoids Journal Article

Nature Communications, 2022.

Abstract | Links | BibTeX | タグ: MaxOne, Neuronal Networks, Organoids

Suppression without inhibition: how retinal computation contributes to saccadic suppression

Idrees, Saad; Baumann, Matthias-Philipp; Korympidou, Maria M; Schubert, Timm; Kling, Alexandra; Franke, Katrin; Hafed, Ziad M; Franke, Felix; Münch, Thomas A

Suppression without inhibition: how retinal computation contributes to saccadic suppression Journal Article

Communications Biology, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, Retina

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration

Wang, F; Li, S; Wang, T Y; Lopez, G A; Antoshechkin, I; Chou, T F

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration Journal Article

Brain Communications, 2022.

Abstract | Links | BibTeX | タグ: MaxTwo

Functional imaging of brain organoids using high-density microelectrode arrays

Schröter Manuel; Wang, Congwei; Terrigno Marco; Hornauer Philipp; Huang Ziqiang; Jagasia Ravi; Hierlemann Andreas

Functional imaging of brain organoids using high-density microelectrode arrays Journal Article

MRS Bulletin, 2022.

Abstract | Links | BibTeX | タグ: HD-MEA, MaxOne, MaxTwo, Organoids

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, Jax H; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Xianfa, ; Yang, ; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | タグ: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne

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