Publications

Discover ~200 publications featuring our technology


All Publications

213 entries « 2 of 5 »

2023

Microfluidic technologies for reconstituting neuronal network functions in vitro

Yamamoto, Hideaki; Hirano-Iwata, Ayumi; Sato, Shigeo

Microfluidic technologies for reconstituting neuronal network functions in vitro Journal Article

JSAP Review, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, HD-MEA, MaxOne, MEA Technology, Microfluidics

Measuring Neuronal Network Activity Using Human Induced Neuronal Cells - Stem Cell-Based Neural Model Systems for Brain Disorders

McSweeney, Danny; English, Jay; Howell, Ethan; Ribbe, Fumiko; Pak, ChangHui

Measuring Neuronal Network Activity Using Human Induced Neuronal Cells - Stem Cell-Based Neural Model Systems for Brain Disorders Book Chapter

Methods in Molecular Biology, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, HD-MEA, IPSC, MaxOne, MEA Metrics, MEA Technology, Network Assay

A CMOS-based highly scalable flexible neural electrode interface

Zhao, Eric T; Hull, Jacob M; Hemed, Nofar Mintz; Ulusan, Hasan; Bartram, Julian; Zhang, Anqi; Wang, Pingyu; Pham, Albert; Silvia Ronchi, John Huguenard R; Hierlemann, Andreas; Melosh, Nicholas A

A CMOS-based highly scalable flexible neural electrode interface Journal Article

Science Advances, 2023.

Abstract | Links | BibTeX | Tags: 3D Culture, HD-MEA, MaxOne, Other Tissues, Slices

Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules

Girardi, Gregory; Zumpano, Danielle; Goshi, Noah; Raybould, Helen; Seker, Erkin

Cultured Vagal Afferent Neurons as Sensors for Intestinal Effector Molecules Journal Article

biosensors, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, HD-MEA, MaxOne, MEA Technology, Primary Neuronal Cell Culture

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking Journal Article

eLife, 2023.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, MEA Metrics, MEA Technology, Modeling, Primary Neuronal Cell Culture, Spike Sorting

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays

Duru, Jens; Maurer, Benedikt; Doran, Ciara Giles; Jelitto, Robert; Küchler, Joël; Ihle, Stephan J; Ruff, Tobias; John, Robert; Genocchi, Barbara; Vörös, János

Investigation of the input-output relationship of engineered neural networks using high-density microelectrode arrays Journal Article

SSRN, 2023.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, MEA Technology, Primary Neuronal Cell Culture, Spike Sorting, Stimulation

The potential of in vitro neuronal networks cultured on Micro Electrode Arrays for biomedical research

Cerina, Marta; Piastra, Maria Carla; Frega, Monica

The potential of in vitro neuronal networks cultured on Micro Electrode Arrays for biomedical research Journal Article

Progress in Biomedical Engineering, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, 3D Culture, Brain Slice, IPSC, MEA Technology, Organoids, Primary Neuronal Cell Culture

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, He Jax; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Yang, Xianfa; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

Cell Regeneration, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, Axon Tracking Assay, HD-MEA, IPSC, MaxOne, MEA Technology, Network Assay, Organoids

Functional imaging of conduction dynamics in cortical and spinal axons

Radivojevic, Milos; Punga, Anna Rostedt

Functional imaging of conduction dynamics in cortical and spinal axons Journal Article

BioRxiv, 2023.

Abstract | Links | BibTeX | Tags: MaxOne

Brain Organoid Computing for Artificial Intelligence

Cai, Hongwei; Ao, Zheng; Tian, Chunhui; Wu, Zhuhao; Liu, Hongcheng; Tchieu, Jason; Gu, Mingxia; Mackie, Ken; and Guo, Feng

Brain Organoid Computing for Artificial Intelligence Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | Tags: HD-MEA, Machine Learning, MaxOne, MEA Technology, Modeling, Organoids, Stimulation

To brain or not to brain organoids

Magliaro, Chiara; Ahluwalia, Arti

To brain or not to brain organoids Journal Article

Frontiers in Science, 2023.

Abstract | Links | BibTeX | Tags: Organoids

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons

Lin, Waka; Shiomoto, Shusaku; Yamada, Saki; Watanabe, Hikaru; Kawashima, Yudai; Eguchi, Yuichi; Muramatsu, Koichi; Sekino, Yuko

Dendritic spine formation and synapse maturation in transcription factor-induced human iPSC-derived neurons Journal Article

iScience, 2023.

Abstract | Links | BibTeX | Tags: Activity Scan Assay, MaxTwo, Network Assay

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons

Qian, Junming; Guan, Xiaonan; Xie, Bing; Xu, Chuanyun; Niu, Jacqueline; Tang, Xin; Li, Charles H; Colecraft, Henry M; Jaenisch, Rudolf; Liu, Shawn X

Multiplex epigenome editing of MECP2 to rescue Rett syndrome neurons Journal Article

Science Translational Medicine, 2023.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, HD-MEA, IPSC, MaxTwo, MEA Technology

A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice

Kim, Eunhee; Jeon, Sungwoong; Yang, Yoon-Sil; Jin, Chaewon; Kim, Jin-young; Oh, Yong- Seok; Rah, Jong-Cheol; and Choi, Hongsoo

A Neurospheroid-Based Microrobot for Targeted Neural Connections in a Hippocampal Slice Journal Article

Advanced Materials, 2023.

Abstract | Links | BibTeX | Tags: MaxOne, microrobot, Organoids, Slices

A Robust Pipeline for the Multi‐Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells

Whye, Dosh; Wood, Delaney; Saber, Wardiya Afshar; Norabuena, Erika M; Makhortova, Nina R; Sahin, Mustafa; Buttermore, Elizabeth D

A Robust Pipeline for the Multi‐Stage Accelerated Differentiation of Functional 3D Cortical Organoids from Human Pluripotent Stem Cells Journal Article

Current Protocols, 2023.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC, Organoids

Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks

Kim, Taehoon; Chen, Dexiong; Hornauer, Philipp; Emmenegger, Vishalini; Bartram, Julian; Ronchi, Silvia; Hierlemann, Andreas; Schröter, Manuel; Roqueiro, Damian

Predicting in vitro single-neuron firing rates upon pharmacological perturbation using Graph Neural Networks Journal Article

Frontiers in Neuroinformatics, 2023.

Abstract | Links | BibTeX | Tags: MaxTwo, Primary Neuronal Cell Culture

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato, Yuya; Yamamoto, Hideaki; Kato, Hideyuki; Tanii, Takashi; Sato, Shigeo; Hirano-Iwata, Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

Frontiers in Neuroscience, 2023.

Abstract | Links | BibTeX | Tags: MaxOne, Neuronal Networks

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

Bartram, Julian; Franke, Felix; Kumar, Sreedhar Saseendran; Buccino, Alessio Paolo; Xue, Xiaohan; Gänswein, Tobias; Schröter, Manuel; Kim, Taehoon; Kasuba, Krishna Chaitanya; Hierlemann, Andreas

Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking Journal Article

bioRxiv, 2023.

Abstract | Links | BibTeX | Tags: CMOS, HD-MEA, Modeling, Primary Neuronal Cell Culture, Spike Sorting

2022

A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement

Han, Xiaobo; Matsuda, Naoki; Ishibashi, Yuto; Odawara, Aoi; Takahashi, Sayuri; Tooi, Norie; Kinoshita, Koshi; Suzuki, Ikuro

A functional neuron maturation device provides convenient application on microelectrode array for neural network measurement Journal Article

Biomaterials Research, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC, MaxOne, Neuronal cell culture, Organoids, Primary Neuronal Cell Culture

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A

Lent, Jonas Van; Vendredy, Leen; Adriaenssens, Elias; Authier, Tatiana Da Silva; Asselbergh, Bob; Kaji, Marcus; Weckhuysen, Sarah; Bosch, Ludo Van Den; Baets, Jonathan; Timmerman, Vincent

Downregulation of PMP22 ameliorates myelin defects in iPSC-derived human organoid cultures of CMT1A Journal Article

Brain, 2022.

Abstract | Links | BibTeX | Tags: Activity Scan Assay, Axon Tracking Assay, MaxTwo, Network Assay, Organoids

Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation

Tran, Hoang-Dai; Shin, Min-Kyoung; Denman, Charlotte; Han, Run-Run; Kuhn, Bernd; Arbuthnott, Gordon; Jo, Junghyun

Generation of Human Striatal-Midbrain Assembloids From Human Pluripotent Stem Cells to Model Alpha-Synuclein Propagation Journal Article

Sneak Peek - Cell Press, 2022.

Abstract | Links | BibTeX | Tags: MaxOne, Organoids

Homophilic wiring principles underpin neuronal network topology in vitro

Akarca, Danyal; Dunn, Alexander W E; Hornauer, Philipp J; Ronchi, Silvia; Fiscella, Michele; Wang, Congwei; Terrigno, Marco; Jagasia, Ravi; Vértes, Petra E; Mierau, Susanna B; Paulsen, Ole; Eglen, Stephen J; Hierlemann, Andreas; Astle, Duncan E; Schröter, Manuel

Homophilic wiring principles underpin neuronal network topology in vitro Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | Tags: MaxOne, MaxTwo, MEA Technology

Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world

Habibollahi, Forough; Khajehnejad, Moein; Gaurav, Amitesh; Kagan, Brett Joseph

Biological Neurons vs Deep Reinforcement Learning: Sample efficiency in a simulated game-world Conference

2022.

Abstract | Links | BibTeX | Tags: Machine Learning, MaxOne

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; and Pak, ChangHui

CASK loss of function differentially regulates neuronal maturation and synaptic function in human induced cortical excitatory neurons Journal Article

iScience, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, CMOS, CRISPR, HD-MEA, MaxOne, Synapses

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Habibollahi, Forough; Khajehnejad, Moein; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

Neuron, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, closed loop stimulation, HD-MEA, IPSC, MaxOne, MEA Metrics, MEA Technology, Primary Neuronal Cell Culture

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays

Habibey, Rouhollah; Striebel, Johannes; Schmieder, Felix; Czarske, Jürgen; Busskamp, Volker

Long-term morphological and functional dynamics of human stem cell-derived neuronal networks on high-density micro-electrode arrays Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne, MEA Metrics, Modeling, Spike Sorting

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study

Kumar, Sreedhar S; Gänswein, Tobias; Buccino, Alessio P; Xue, Xiaohan; Bartram, Julian; Emmenegger, Vishalini; Hierlemann, Andreas

Tracking axon initial segment plasticity using high-density microelectrode arrays: A computational study Journal Article

Frontiers in Neuroinformatics, 2022.

Abstract | Links | BibTeX | Tags: CMOS, HD-MEA, MEA Technology

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells

Lee, Jihyun; Gänswein, Tobias; Ulusan, Hasan; Emmenegger, Vishalini; Saguner, Ardan M; Duru, Firat; and Hierlemann, Andreas

Repeated and On-Demand Intracellular Recordings of Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells Journal Article

ACS Sensors, 2022.

Abstract | Links | BibTeX | Tags: Cardiomyocytes, CMOS, HD-MEA, MaxOne, MEA Technology

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus

Al-Absi, Abdel-Rahman; Thambiappaa, Sakeerthi Kethees; Khanc, Ahmad Raza; Glerup, Simon; Sanchez, Connie; Landau, Anne M; Nyengaard, Jens R

Df(h22q11)/+ mouse model exhibits reduced binding levels of GABAA receptors and structural and functional dysregulation in the inhibitory and excitatory networks of hippocampus Journal Article

Molecular and Cellular Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: Brain Slice, CMOS, HD-MEA, MaxOne

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays

Buccino Alessio Paolo; Damart, Tanguy; Bartram Julian; Mandge Darshan; Xue Xiaohan; Zbili Mickael; Gänswein Tobias; Jaquier Aurélien; Emmenegger Vishalini; Markram Henry; Hierlemann Andreas; Van Geit Werner.

A multi-modal fitting approach to construct single-neuron models with patch clamp and high-density microelectrode arrays Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, Axon Tracking Assay, HD-MEA, MaxOne, Other Tissues, Publication, Stimulation Assay

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan; Buccino, Alessio Paolo; Kumar, Sreedhar Saseendran; Hierlemann, Andreas; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

Journal of Neural Engineering, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Assay, HD-MEA, MaxOne, Network Assay, Primary Neuronal Cell Culture, Publication

Functional neuronal circuitry and oscillatory dynamics in human brain organoids

Sharf Tal; Molen, Tjitse; Glasauer Stella; Guzman Elmer; Buccino Alessio; Luna Gabriel; Cheng Zhuowei; Audouard Morgane; Ranasinghe Kamalini; Kudo Kiwamu; Nagarajan Srikantan; Tovar Kenneth; Petzold Linda; Hierlemann Andreas; Hansma Paul; ; Kosik, Kenneth;

Functional neuronal circuitry and oscillatory dynamics in human brain organoids Journal Article

Nature Communications, 2022.

Abstract | Links | BibTeX | Tags: MaxOne, Neuronal Networks, Organoids

Suppression without inhibition: how retinal computation contributes to saccadic suppression

Idrees, Saad; Baumann, Matthias-Philipp; Korympidou, Maria M; Schubert, Timm; Kling, Alexandra; Franke, Katrin; Hafed, Ziad M; Franke, Felix; Münch, Thomas A

Suppression without inhibition: how retinal computation contributes to saccadic suppression Journal Article

Communications Biology, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Retina

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration

Wang, F; Li, S; Wang, T Y; Lopez, G A; Antoshechkin, I; Chou, T F

P97/VCP ATPase inhibitors can rescue p97 mutation-linked motor neuron degeneration Journal Article

Brain Communications, 2022.

Abstract | Links | BibTeX | Tags: MaxTwo

Functional imaging of brain organoids using high-density microelectrode arrays

Schröter Manuel; Wang, Congwei; Terrigno Marco; Hornauer Philipp; Huang Ziqiang; Jagasia Ravi; Hierlemann Andreas

Functional imaging of brain organoids using high-density microelectrode arrays Journal Article

MRS Bulletin, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, MaxTwo, Organoids

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells

Xu, Jax H; Yao, Yao; Yao, Fenyong; Chen, Jiehui; Li, Meishi; Xianfa, ; Yang, ; Li, Sheng; Lu, Fangru; Hu, Ping; He, Shuijin; Peng, Guangdun; Jing, Naihe

Generation of functional posterior spinal motor neurons from hPSCs-derived human spinal cord neural progenitor cells Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, CMOS, HD-MEA, IPSC, MaxOne

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Sommer Daniel ; Rajkumar, Sandeep; Seidel Mira; Aly Amr; Ludolph Albert; Ho Ritchie; Boeckers Tobias; Catanese Alberto.

Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons Journal Article

Frontiers in Molecular Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Automated detection of extracellular action potentials from single neurons

Cheng, Zhuowei; Guzman, Elmer; van der Molen, Tjitse; Sharf, Tal; Hansma, Paul K; Kosik, Kenneth S; Petzold, Linda; Tovar, Kenneth R

Automated detection of extracellular action potentials from single neurons Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: Action Potential, HD-MEA, MaxOne

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability

Noh Seungmin ; Jeon, Sungwoong; Kim Eunhee; Oh Untaek; Park Danbi; Park Sun Hwa; Kim Sung Won; Pané Salvador; Nelson Bradley; Kim Jin-young; Choi Hongsoo;

A Biodegradable Magnetic Microrobot Based on Gelatin Methacrylate for Precise Delivery of Stem Cells with Mass Production Capability Journal Article

Small, 2022.

Abstract | Links | BibTeX | Tags: MaxOne

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks

Sato Yuya; Yamamoto, Hideaki; Kato Hideyuki; Tanii Takashi; Sato Shigeo; Hirano-Iwata Ayumi

Microfluidic cell engineering on high-density microelectrode arrays for assessing structure-function relationships in living neuronal networks Journal Article

2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array

Shimba Kenta; Asahina, Takahiro; Sakai Koji; Kotani Kiyoshi; Jimbo Yasuhiko

Recording Saltatory Conduction Along Sensory Axons Using a High-Density Microelectrode Array Journal Article

Frontiers in Neuroscience, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal cell culture

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation

Hornauer Philipp; Prack, Gustavo; Anastasi Nadia; Ronchi Silvia; Kim Taehoon; Donner Christian; Fiscella Michele; Borgwardt Karsten; Taylor Verdon; Jagasia Ravi; Roqueiro Damian; Hierlemann Andreas;

Downregulating α-synuclein in iPSC-derived dopaminergic neurons mimics 2 electrophysiological phenotype of the A53T mutation Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal cell culture

Design strategies for controlling neuron-connected robots using reinforcement learning

Sawada, Haruto; Wake, Naoki; Sasabuchi, Kazuhiro; Takamatsu, Jun; Takahashi, Hirokazu; Ikeuchi, Katsushi

Design strategies for controlling neuron-connected robots using reinforcement learning Journal Article

arXiv, 2022.

Abstract | Links | BibTeX | Tags: Machine Learning, MaxOne, Stimulation

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays

Duru Jens; Küchler, Joël; Ihle Stephan Forró Csaba; Bernardi Aeneas; Girardin Sophie; Hengsteler Julian; Wheeler Stephen; János; Ruff Tobias; J ; Vörös

Engineered Biological Neural Networks on High Density CMOS Microelectrode Arrays Journal Article

2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Neuronal Networks

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking

Xue, Xiaohan ; Buccino, Alessio Paolo ; Kumar, Sreedhar Saseendran ; Hierlemann, Andreas ; Bartram, Julian

Inferring monosynaptic connections from paired dendritic spine Ca2+ imaging and large-scale recording of extracellular spiking Journal Article

bioRxiv, 2022.

Abstract | Links | BibTeX | Tags: ETH-CMOS-MEA, Neuronal Networks

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons

McSweeney, Danny; Gabriel, Rafael; Jin, Kang; Pang, Zhiping P; Aronow, Bruce; Pak, ChangHui

Loss of Neurodevelopmental Gene CASK Disrupts Neural Connectivity in Human Cortical Excitatory Neurons Journal Article

BioRxiv, 2022.

Abstract | Links | BibTeX | Tags: IPSC, MaxOne, Neuronal Networks

Autism genes converge on asynchronous development of shared neuron classes

Paulsen, Bruna; Velasco, Silvia; Kedaigle, Amanda J; Pigoni, Martina; Quadrato, Giorgia; Deo, Anthony J; Adiconis, Xian; Uzquiano, Ana; Sartore, Rafaela; Yang, Sung Min; Simmons, Sean K; Symvoulidis, Panagiotis; Kim, Kwanho; Tsafou, Kalliopi; Podury, Archana; Abbate, Catherine; Tucewicz, Ashley; Smith, Samantha N; Albanese, Alexandre; Barrett, Lindy; Sanjana, Neville E; Shi, Xi; Chung, Kwanghun; Lage, Kasper; Boyden, Edward S; andJoshua Levin, Aviv Regev Z; Arlotta, Paola

Autism genes converge on asynchronous development of shared neuron classes Journal Article

Nature, 602 , pp. 268–273, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, MaxOne, Organoids

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders

McCready, Fraser P; Gordillo-Sampedro, Sara; Pradeepan, Kartik; Martinez-Trujillo, Julio; Ellis, James

Multielectrode Arrays for Functional Phenotyping of Neurons from Induced Pluripotent Stem Cell Models of Neurodevelopmental Disorders Journal Article

Biology, 2022.

Abstract | Links | BibTeX | Tags: HD-MEA, IPSC, MaxOne, MEA Technology

2021

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

Hruska-Plochan, Marian; Betz, Katharina M; Ronchi, Silvia; Wiersma, Vera I; Maniecka, Zuzanna; Hock, Eva-Maria; Laferriere, Florent; Sahadevan, Sonu; Hoop, Vanessa; Delvendahl, Igor; Panatta, Martina; van der Bourg, Alexander; Bohaciakova, Dasa; Frontzek, Karl; Aguzzi, Adriano; Lashley, Tammaryn; Robinson, Mark D; Karayannis, Theofanis; Mueller, Martin; Hierlemann, Andreas; Polymenidou, Magdalini

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD Journal Article

BioRxiv, 2021.

Abstract | Links | BibTeX | Tags: Inhibitory Neurons, MEA Technology, Neuronal Networks

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world

Kagan, Brett J; Kitchen, Andy C; Tran, Nhi T; Parker, Bradyn J; Bhat, Anjali; Rollo, Ben; Razi, Adeel; Friston, Karl J

In vitro neurons learn and exhibit sentience when embodied in a simulated game-world Journal Article

bioRxiv, 2021.

Abstract | Links | BibTeX | Tags: 2D Neuronal Culture, Activity Scan Assay, closed loop stimulation, HD-MEA, In-Vitro, IPSC, MaxOne, MEA Technology, Network Assay, Neuronal Networks, Primary Neuronal Cell Culture, Stimulation

213 entries « 2 of 5 »

Selected Publications

Mueller2015

High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

Presenting measurements of neuronal preparations with a novel CMOS-based microelectrode array at high-spatiotemporal-resolution on subcellular, cellular, and network level.

J. Müller, M. Ballini, P. Livi, Y. Chen, M. Radivojevic, A. Shadmani, V. Viswam, I. L. Jones, M. Fiscella, R. Diggelmann, A. Stettler, U. Frey, D. J. Bakkum, and A. Hierlemann, “High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels,” Lab Chip, vol. 15, no. 13, pp. 2767–2780, May 2015.

Obien2014

Revealing Neuronal Function through Microelectrode Array Recordings

Reviewing the current understanding of microelectrode signals and the techniques for analyzing them, with focus on the ongoing advancements in microelectrode technology (in vivo and in vitro) and recent advanced microelectrode array measurement methods that facilitate the understanding of single neurons and network function.

M. E. J. Obien, K. Deligkaris, T. Bullmann, D. J. Bakkum, and U. Frey, “Revealing Neuronal Function through Microelectrode Array Recordings,” Front. Neurosci., 8:423, Jan 2015.

Ballini2014

A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro

A high-resolution CMOS-based microelectrode array featuring 1,024 low-noise readout channels, 26,400 electrodes at a density of 3,265 electrodes per mm2, including on-chip 10bit ADCs and consuming only 75 mW.

M. Ballini, J. Muller, P. Livi, Y. Chen, U. Frey, A. Stettler, A. Shadmani, V. Viswam, I. L. Jones, D. Jackel, M. Radivojevic, M. K. Lewandowska, W. Gong, M. Fiscella, D. J. Bakkum, F. Heer, and A. Hierlemann, “A 1024-Channel CMOS Microelectrode Array With 26,400 Electrodes for Recording and Stimulation of Electrogenic Cells In Vitro,” IEEE Journal of Solid-State Circuits, vol. 49, no. 11, pp. 2705-2719, 2014.

Bakkum2013ncomm

Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

Demonstrating a method to electrically visualize action potential propagation on axons and revealing
large variations in velocity.

D. J. Bakkum, U. Frey, M. Radivojevic, T. L. Russell, J. Muller, M. Fiscella, H. Takahashi, and A. Hierlemann, “Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites,” Nature Communications, 4:2181, Jul 2013.

Frey08BioSensors

Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices

Recording and modeling extracellular action potentials of Purkinje cells at subcellular resolution.

U. Frey, U. Egert, F. Heer, S. Hafizovic, and A. Hierlemann, “Microelectronic System for High-Resolution Mapping of Extracellular Electric Fields Applied to Brain Slices,” Biosensors and Bioelectronics, vol. 24, no. 7, pp. 2191-2198, 2009.

SanchezBustamante07NRC

Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression

Controlling BMP-2 expression to modulate the electrophysiological properties of cardiomyocytes using an HD-MEA for detailed monitoring.

C. D. Sanchez-Bustamante, U. Frey, J. M. Kelm, A. Hierlemann, and M. Fussenegger,
“Modulation of Cardiomyocyte Electrical Properties Using Regulated Bone Morphogenetic Protein-2 Expression,” Tissue Engineering Part A, vol. 14, no. 12, pp. 1969-1988, 2008.

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